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| Neurogenetic dissection of learning-by-doing in Drosophila | |||
| Author | Björn Brembs | ||
| Author email | bjoern©brembs.net | ||
| Author website | http://brembs.net | ||
| Description | The “generation effect” is the psychological phenomenon underlying learning-by-doing and entails that information will be remembered better if it is actively generated rather than passively perceived. Genetic dissection of the active and passive learning components underlying the generation effect in Drosophila revealed two reciprocal interactions between them. Active and passive learning components interact not only to enhance learning but simultaneously enable generalization and prevent premature habit formation. The learning gene rutabaga and the mushroom-body neuropil were specifically involved only in passive fact-learning and the interaction mediating generalization, respectively, but not in active skill-learning and the interaction enhancing learning. Extended training in wildtype flies abolished generalization and led to habit formation, constituting a phenocopy of mushroom-body impaired flies. These findings allow for the detailed analysis of the circuitry and the molecular processes underlying learning-by-doing. | ||
| Image | no image available | ||
| Filesize | 9.72 MB | ||
| Downloads | 1096 | ||
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